COVID-19: There’s no Treatment but Researchers are Getting Creative.

Covid-19 blood

Those of us alive today may have never seen anything like the ongoing 2019 coronavirus pandemic. It therefore makes critical sense to have interest in any pilot study on the pandemic that looks at existing therapies, experimental procedures and traditional medicines. News of garlic and other panacea have no clinical evidence. However, early studies from ground zero in Wuhan, China show that the disease mostly kills the elderly and immunocompromised (sick people), and kills them partly through a cytokine storm (death from increased inflammation). Therefore targeting markers of inflammation like interleukins and interferon-gamma has been exploited in China with Roche’s Actemra (used to treat arthritis), as well as use of antibodies from blood plasma obtained from patients that have recovered from Covid-19. The 1995 movie “Outbreak” is trending on Netflix and dramatizes the importance of using blood from recovering patients to treat the sick. Antivirals like Gilead’s remdesivir and AbbVie’s anti-HIV Kaletra are also being exploited in this pandemic. Doctors also use antibiotics to treat secondary infections which have proven deadly. Vaccines take 1-2 years to develop and be available for use.

Articles reviewed for this post:

Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., … Shang, Y. (2020, February 24). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine. doi: 10.1016/s2213-2600(20)30079-5

Cron, R., & Chatham, W. W. (2020, March 12). How doctors can potentially significantly reduce the number of deaths from Covid-19. Retrieved from https://www.vox.com/2020/3/12/21176783/coronavirus-covid-19-deaths-china-treatment-cytokine-storm-syndrome

Bloomberg. (2020, February 14). China finds promising coronavirus treatment in blood plasma from recovered patients. Retrieved from https://fortune.com/2020/02/14/china-coronavirus-treatment-blood-plasma-recovered-patients/

Liu, A. (2020, March 4). China turns Roche arthritis drug Actemra against COVID-19 in new treatment guidelines. Retrieved from https://www.fiercepharma.com/pharma-asia/china-turns-roche-arthritis-drug-actemra-against-covid-19-new-treatment-guidelines

Outbreak. (1995, March 10). Retrieved from https://www.boxofficemojo.com/title/tt0114069/?ref_=bo_rl_ti

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